oral iron efficiency

How to tell if oral iron is working?

If you’re taking oral iron of any kind, give it 2 weeks to judge how well it’s working and will continue to work. ref

A ≥ 10 mmol/L increase in hemoglobin on day 14 most accurately predicted satisfactory overall hemoglobin response to oral iron on day 42/56 (sensitivity 90.1%; specificity 79.3%; positive and negative predictive values of 92.9% and 72.7%, respectively). Iron-replacement therapy improved quality of life and reduced fatigue.

 

Hemoglobin responses < 10 mmol/L at day 14 of oral iron identify subjects with iron-deficiency anemia who should be transitioned to IV iron supplementation.

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We know, it doesn’t make intuitive sense to take less iron when you need more of it. Our body does something interesting when it gets too much iron